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ORIGINAL ARTICLES
Year : 2020  |  Volume : 25  |  Issue : 1  |  Page : 11-15

Curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat


1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria
2 Department of Chemical Pathology, Faculty of Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria

Correspondence Address:
Dr. Nto J Nto
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, Enugu.
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmh.IJMH_22_19

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Background: Male reproductive dysfunction is a common health concern and can affect the quality of life. This study evaluated the curative effect of aqueous extract of the bark of Boswellia dalzielii on flutamide-induced testicular toxicity in Wistar rat. Materials and Methods: Sixteen male Wistar rats were randomly divided into four groups of four rats each, labeled Groups A–D. Group A was the negative control, Group B (positive control) received 10 mg/kg body weight of flutamide. Groups C and D were given 10 mg/kg body weight of flutamide per day for 7 days and discontinued, they were treated with 100 and 300 mg/kg body weight of aqueous extract of B. dalzielii, respectively, from days 8 to 21. All administrations were carried out orally. Results: There was a dose-dependent increase in body weight, raised serum testosterone levels, and increased cellular proliferation following administration of B. dalzielii on flutamide-induced testicular toxicity. Conclusion: The result of this study suggests that the aqueous extract of the bark of B. dalzielii has a therapeutic effect on flutamide-induced testicular toxicity.


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