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Year : 2007  |  Volume : 12  |  Issue : 2  |  Page : 89-92

Pattern of serum high density lipoprotein distribution in a malaria endemic Population: A study in Enugu

1 Department of pharmacology, College of Medicine, ESUT, Enugu, Nigeria
2 Department of pharmacology and Therapeutics, Faculty of Medical Sciences, UNEC, Enugu, Nigeria
3 Department of pharmacology and Therapeutics, Faculty of Medicine, College of Health Sciences, N.A.U., Nnewi, Nigeria
4 Department of physiology, Faculty of Medicine, College of Health Sciences, N.A.U., Nnewi, Nigeria

Correspondence Address:
MB.BS,M.Sc Ndubuisi Nwobodo
Department of Pharmacology, Faculty of Medical Sciences, College of Medicine, Enugu State University of Science and Technology, Enugu
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Source of Support: None, Conflict of Interest: None

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Aim: To characterize the effect of malaria infection on serum HDL levels with respect to age and sex distribution in an endemic population. Patients and Methods: A total of sixty subjects within the age range of 10 to 60 years were selected by stratified random sampling from patients attending the general out-patient department of a district hospital in Enugu. Serum HDL fractions were determined in both malaria patients and healthy control subjects. Data obtained was statistically analyzed using ANOVA, assuming P<0.05 as significant and presented in tabular form. Results: The study revealed a consistent age-related decline in serum HDL values in both malaria patients and control. However, the mean HDL values were noted to be significantly elevated in malaria patients relative to control, (P<0.05). Conclusion: The serum HDL fraction may be implicated in the pathogenesis of malaria infection especially in the disease endemic zones.

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